Specific Inhibitor of Smad3 (SIS3) Attenuates Fibrosis, Apoptosis, and Inflammation in Unilateral Ureteral Obstruction Kidneys by Inhibition of Transforming Growth Factor β (TGF-β)/Smad3 Signaling

BACKGROUND: Fibrosis is the common pathological feature in most kinds of chronic kidney disease (CKD). TGF-β/Smads signaling is the master pathway regulating kidney fibrosis pathogenesis, in which Smad3 acts as the integrator of various pro-fibrosis signals. In this study, we analyzed the role of SI...

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Detalles Bibliográficos
Autores principales: Ji, Xingli, Wang, Honglian, Wu, Zhaojun, Zhong, Xia, Zhu, Menglian, Zhang, Yuwei, Tan, Ruizhi, Liu, Yuhang, Li, Jianchun, Wang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Animal Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872904/
https://www.ncbi.nlm.nih.gov/pubmed/29555895
http://dx.doi.org/10.12659/MSM.909236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872904/
https://www.ncbi.nlm.nih.gov/pubmed/29555895
http://dx.doi.org/10.12659/MSM.909236

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