Molecular dynamics simulation study on the structural instability of the most common cystic fibrosis-associated mutant ΔF508-CFTR

Cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that belongs to the ATP binding cassette protein superfamily. Deletion of phenylalanine at position 508 (ΔF508) is the most common CF-associated mutation and is present in nearly 90% of CF patients. Currently, atomistic l...

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Detalles Bibliográficos
Autores principales: Odera, Mitsuhiko, Furuta, Tadaomi, Sohma, Yoshiro, Sakurai, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Biophysical Society of Japan (BSJ) 2018
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873040/
https://www.ncbi.nlm.nih.gov/pubmed/29607278
http://dx.doi.org/10.2142/biophysico.15.0_33

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873040/
https://www.ncbi.nlm.nih.gov/pubmed/29607278
http://dx.doi.org/10.2142/biophysico.15.0_33

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