Structural basis and energy landscape for the Ca(2+) gating and calmodulation of the Kv7.2 K(+) channel

The Kv7.2 (KCNQ2) channel is the principal molecular component of the slow voltage-gated, noninactivating K(+) M-current, a key controller of neuronal excitability. To investigate the calmodulin (CaM)-mediated Ca(2+) gating of the channel, we used NMR spectroscopy to structurally and dynamically des...

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Detalles Bibliográficos
Autores principales: Bernardo-Seisdedos, Ganeko, Nuñez, Eider, Gomis, Carolina, Malo, Covadonga, Villarroel, Álvaro, Millet, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873240/
https://www.ncbi.nlm.nih.gov/pubmed/29463698
http://dx.doi.org/10.1073/pnas.1800235115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873240/
https://www.ncbi.nlm.nih.gov/pubmed/29463698
http://dx.doi.org/10.1073/pnas.1800235115

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