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Structural basis and energy landscape for the Ca(2+) gating and calmodulation of the Kv7.2 K(+) channel
The Kv7.2 (KCNQ2) channel is the principal molecular component of the slow voltage-gated, noninactivating K(+) M-current, a key controller of neuronal excitability. To investigate the calmodulin (CaM)-mediated Ca(2+) gating of the channel, we used NMR spectroscopy to structurally and dynamically des...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873240/ https://www.ncbi.nlm.nih.gov/pubmed/29463698 http://dx.doi.org/10.1073/pnas.1800235115 |