Disruption of IGF-1R signaling by a novel quinazoline derivative, HMJ-30, inhibits invasiveness and reverses epithelial-mesenchymal transition in osteosarcoma U-2 OS cells

Osteosarcoma is the most common primary malignancy of the bone and is characterized by local invasion and distant metastasis. Over the past 20 years, long-term outcomes have reached a plateau even with aggressive therapy. Overexpression of insulin-like growth factor 1 receptor (IGF-1R) is associated...

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Detalles Bibliográficos
Autores principales: Chiu, Yu-Jen, Hour, Mann-Jen, Jin, Yi-An, Lu, Chi-Cheng, Tsai, Fuu-Jen, Chen, Tai-Lin, Ma, Hsu, Juan, Yu-Ning, Yang, Jai-Sing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873869/
https://www.ncbi.nlm.nih.gov/pubmed/29568964
http://dx.doi.org/10.3892/ijo.2018.4325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873869/
https://www.ncbi.nlm.nih.gov/pubmed/29568964
http://dx.doi.org/10.3892/ijo.2018.4325

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