The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer

The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in several human cancers. We noted that in a substantial percentage of colon cancers, FBW7 protein is undetectable despite the presence of FBW7 mRNA. To understand the molecular mechanism of FBW7 regulatio...

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Detalles Bibliográficos
Autores principales: Khan, Omar M., Carvalho, Joana, Spencer-Dene, Bradley, Mitter, Richard, Frith, David, Snijders, Ambrosius P., Wood, Stephen A., Behrens, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873885/
https://www.ncbi.nlm.nih.gov/pubmed/29346117
http://dx.doi.org/10.1172/JCI97325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873885/
https://www.ncbi.nlm.nih.gov/pubmed/29346117
http://dx.doi.org/10.1172/JCI97325

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