Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score

BACKGROUND: Since 1946 the controlled human infection model (CHIM) for Shigella has been used to improve understanding of disease pathogenesis, describe clinical and immunologic responses to infection and as a tool for vaccine development. As the frequency and intent for use in vaccine comparisons i...

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Detalles Bibliográficos
Autores principales: Porter, Chad K., Lynen, Amanda, Riddle, Mark S., Talaat, Kawsar, Sack, David, Gutiérrez, Ramiro L., McKenzie, Robin, DeNearing, Barbara, Feijoo, Brittany, Kaminski, Robert W., Taylor, David N., Kirkpatrick, Beth D., Bourgeois, A. Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874036/
https://www.ncbi.nlm.nih.gov/pubmed/29590182
http://dx.doi.org/10.1371/journal.pone.0194325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874036/
https://www.ncbi.nlm.nih.gov/pubmed/29590182
http://dx.doi.org/10.1371/journal.pone.0194325

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