PARP1 depletion induces RIG-I-dependent signaling in human cancer cells

DNA Damage Response (DDR) and DNA repair pathways are emerging as potent, ubiquitous suppressors of innate immune signaling in human cells. Here, we show that human cells surviving depletion of the Single Strand Break (SSB) repair protein PARP1 undergo p21-dependent senescence or cell cycle checkpoi...

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Detalles Bibliográficos
Autores principales: Ghosh, Rajib, Roy, Sanchita, Franco, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874037/
https://www.ncbi.nlm.nih.gov/pubmed/29590171
http://dx.doi.org/10.1371/journal.pone.0194611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874037/
https://www.ncbi.nlm.nih.gov/pubmed/29590171
http://dx.doi.org/10.1371/journal.pone.0194611

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