Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

Despite the wide availability of antibiotics, infectious diseases remain a leading cause of death worldwide.(1) In the absence of new therapies, mortality rates due to untreatable infections are predicted to rise more than 10-fold by 2050. Natural products (NPs) made by cultured bacteria have been a...

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Detalles Bibliográficos
Autores principales: Hover, Bradley M., Kim, Seong-Hwan, Katz, Micah, Charlop-Powers, Zachary, Owen, Jeremy G., Ternei, Melinda A., Maniko, Jeffrey, Estrela, Andreia, Molina, Henrik, Park, Steven, Perlin, David S., Brady, Sean F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874163/
https://www.ncbi.nlm.nih.gov/pubmed/29434326
http://dx.doi.org/10.1038/s41564-018-0110-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874163/
https://www.ncbi.nlm.nih.gov/pubmed/29434326
http://dx.doi.org/10.1038/s41564-018-0110-1

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