Cargando…

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP(5+), Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation

Radiation injury to the lung is the result of acute and chronic free radical formation, and there are currently few effective means of mitigating such injury. Studies in rodents indicate that superoxide dismutase mimetics may be effective in this regard; however, studies in humans or large animals a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cline, John Mark, Dugan, Greg, Bourland, John Daniel, Perry, Donna L., Stitzel, Joel D., Weaver, Ashley A., Jiang, Chen, Tovmasyan, Artak, Owzar, Kouros, Spasojevic, Ivan, Batinic-Haberle, Ines, Vujaskovic, Zeljko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874526/ https://www.ncbi.nlm.nih.gov/pubmed/29518913 http://dx.doi.org/10.3390/antiox7030040

Ejemplares similares

Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+)()
por: Gauter-Fleckenstein, Benjamin, et al.
Publicado: (2014)

Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP(4+), in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H(2)O)MnTnHex-2-PyP(5+)
por: Li, Litao, et al.
Publicado: (2020)

The SOD Mimic MnTnHex-2-PyP(5+) Reduces the Viability and Migration of 786-O Human Renal Cancer Cells
por: Costa, João G., et al.
Publicado: (2019)

MnTnHex-2-PyP(5+) Displays Anticancer Properties and Enhances Cisplatin Effects in Non-Small Cell Lung Cancer Cells
por: Soares, Rita B., et al.
Publicado: (2022)

MnTnHex-2-PyP(5+), Coupled to Radiation, Suppresses Metastasis of 4T1 and MDA-MB-231 Breast Cancer via AKT/Snail/EMT Pathways
por: Shin, Sung-Won, et al.
Publicado: (2021)

CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP(5+)
por: Leu, David, et al.
Publicado: (2017)

The manganese(III) porphyrin MnTnHex-2-PyP(5+) modulates intracellular ROS and breast cancer cell migration: Impact on doxorubicin-treated cells
por: Flórido, Ana, et al.
Publicado: (2018)

A Redox-active Mn Porphyrin, MnTnBuOE-2-PyP(5+), Synergizes with Carboplatin in Treatment of Chemoresistant Ovarian Cell Line
por: Chaiswing, Luksana, et al.
Publicado: (2022)

Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum()
por: Archambeau, John O., et al.
Publicado: (2013)

Porphyrin‐Based SOD Mimic MnTnBuOE‐2‐PyP(5+) Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis
por: Anselmo, Wanda, et al.
Publicado: (2018)

Photoinactivation of Yeast and Biofilm Communities of Candida albicans Mediated by ZnTnHex-2-PyP(4+) Porphyrin
por: Souza, Sueden O., et al.
Publicado: (2022)

Mn(III) Porphyrin, MnTnBuOE-2-PyP(5+), Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress
por: Sharma, Sudha, et al.
Publicado: (2023)

Corrigendum to ‘An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins – From superoxide dismutation to H(2)O(2)-driven pathways’ [Redox Biology 5C (2015) 43–65]
por: Batinic-Haberle, Ines, et al.
Publicado: (2015)

An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins – From superoxide dismutation to H(2)O(2)-driven pathways
por: Batinic-Haberle, Ines, et al.
Publicado: (2015)

A novel redox regulator, MnTnBuOE-2-PyP(5+), enhances normal hematopoietic stem/progenitor cell function
por: Zhao, Y., et al.
Publicado: (2017)

Intracarotid Infusion of Redox-Active Manganese Porphyrin, MnTnBuOE-2-PyP(5+), following Reperfusion Improves Long-Term, 28-Day Post-Stroke Outcomes in Rats
por: Li, Xuan, et al.
Publicado: (2023)

Design, Mechanism of Action, Bioavailability and Therapeutic Effects of Mn Porphyrin-Based Redox Modulators
por: Tovmasyan, Artak, et al.
Publicado: (2013)

The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP(5+), Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin
por: Soares, Rita B., et al.
Publicado: (2023)

Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae
por: Li, Alice Ma, et al.
Publicado: (2014)

Nanoformulation of the superoxide dismutase mimic, MnTnBuOE-2-PyP(5+), prevents its acute hypotensive response
por: Schlichte, Sarah L., et al.
Publicado: (2020)

MnTE-2-PyP protects fibroblast mitochondria from hyperglycemia and radiation exposure
por: Chatterjee, Arpita, et al.
Publicado: (2022)

Antibacterial Activity of Synthetic Cationic Iron Porphyrins
por: Tovmasyan, Artak, et al.
Publicado: (2020)

MnTnBuOE-2-PyP protects normal colorectal fibroblasts from radiation damage and simultaneously enhances radio/chemotherapeutic killing of colorectal cancer cells
por: Kosmacek, Elizabeth A., et al.
Publicado: (2016)

Radioprotective and tumor antiangiogenic effect of the novel synthetic superoxide dismutase (SOD) mimetic compounds
por: Vujaskovic, Z, et al.
Publicado: (2001)

Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes
por: Hasan, Bader, et al.
Publicado: (2021)

Rational Design of Superoxide Dismutase (SOD) Mimics: The Evaluation of the Therapeutic Potential of New Cationic Mn Porphyrins with Linear and Cyclic Substituents
por: Tovmasyan, Artak, et al.
Publicado: (2014)

Sublethal Photodynamic Treatment Does Not Lead to Development of Resistance
por: Al-Mutairi, Rawan, et al.
Publicado: (2018)

The Antioxidant, MnTE-2-PyP, Prevents Side-Effects Incurred by Prostate Cancer Irradiation
por: Oberley-Deegan, Rebecca E., et al.
Publicado: (2012)

Post-illumination cellular effects of photodynamic treatment
por: Charara, Malak, et al.
Publicado: (2017)

MnTnBuOE-2-PyP treatment protects from radioactive iodine (I-131) treatment-related side effects in thyroid cancer
por: Patel, Anery, et al.
Publicado: (2019)

Assessing the Effects of Redox Modifier MnTnBuOE-2-PyP 5+ on Cognition and Hippocampal Physiology Following Doxorubicin, Cyclophosphamide, and Paclitaxel Treatment
por: McElroy, Taylor, et al.
Publicado: (2020)

Redox-Active Drug, MnTE-2-PyP(5+), Prevents and Treats Cardiac Arrhythmias Preserving Heart Contractile Function
por: Barbosa, Andrezza M., et al.
Publicado: (2020)

Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications()
por: Ali, Dana K., et al.
Publicado: (2013)

Superoxide Dismutase Mimic, MnTE-2-PyP Enhances Rectal Anastomotic Strength in Rats after Preoperative Chemoradiotherapy
por: Yang, Yu, et al.
Publicado: (2020)

Antioxidant Effect of MnTE-2-PyP on Lung in Asthma Mice Model
por: Terziev, Lyudmil, et al.
Publicado: (2012)

H(2)O(2)-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways
por: Batinic-Haberle, Ines, et al.
Publicado: (2021)

Targeting Mitochondria by Zn(II)N-Alkylpyridylporphyrins: The Impact of Compound Sub-Mitochondrial Partition on Cell Respiration and Overall Photodynamic Efficacy
por: Odeh, Ahmad M., et al.
Publicado: (2014)

The Metalloporphyrin Antioxidant, MnTE-2-PyP, Inhibits Th2 Cell Immune Responses in an Asthma Model
por: Jungsuwadee, Paiboon, et al.
Publicado: (2012)

Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells
por: Ghandhi, Shanaz A., et al.
Publicado: (2018)

The SOD Mimic, MnTE-2-PyP, Protects from Chronic Fibrosis and Inflammation in Irradiated Normal Pelvic Tissues
por: Shrishrimal, Shashank, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nlurtse0oqiq1c2uc2mj0q5m24