A Novel Interaction Between the TLR7 and a Colchicine Derivative Revealed Through a Computational and Experimental Study

The Toll-Like Receptor 7 (TLR7) is an endosomal membrane receptor involved in the innate immune system response. Its best-known small molecule activators are imidazoquinoline derivatives such as imiquimod (R-837) and resiquimod (R-848). Recently, an interaction between R-837 and the colchicine bindi...

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Detalles Bibliográficos
Autores principales: Gentile, Francesco, Deriu, Marco A., Barakat, Khaled H., Danani, Andrea, Tuszynski, Jack A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874718/
https://www.ncbi.nlm.nih.gov/pubmed/29462934
http://dx.doi.org/10.3390/ph11010022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874718/
https://www.ncbi.nlm.nih.gov/pubmed/29462934
http://dx.doi.org/10.3390/ph11010022

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