A π-Halogen Bond of Dibenzofuranones with the Gatekeeper Phe113 in Human Protein Kinase CK2 Leads to Potent Tight Binding Inhibitors

Human protein kinase CK2 is an emerging target for neoplastic diseases. Potent lead structures for human CK2 inhibitors are derived from dibenzofuranones. Two new derivatives, 7,9-dichloro-1,2-dihydro-8-hydroxy-4-[(4-methoxyphenylamino)-methylene]dibenzo[b,d]furan-3(2H)-one (4a) and (E)-1,3-dichloro...

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Detalles Bibliográficos
Autores principales: Schnitzler, Alexander, Gratz, Andreas, Bollacke, Andre, Weyrich, Michael, Kuckländer, Uwe, Wünsch, Bernhard, Götz, Claudia, Niefind, Karsten, Jose, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874719/
https://www.ncbi.nlm.nih.gov/pubmed/29462988
http://dx.doi.org/10.3390/ph11010023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874719/
https://www.ncbi.nlm.nih.gov/pubmed/29462988
http://dx.doi.org/10.3390/ph11010023

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