The Evolutionary unZIPping of a Dimerization Motif—A Comparison of ZIP and PrP Architectures

The cellular prion protein, notorious for its causative role in a range of fatal neurodegenerative diseases, evolved from a Zrt-/Irt-like Protein (ZIP) zinc transporter approximately 500 million years ago. Whilst atomic structures for recombinant prion protein (PrP) from various species have been av...

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Detalles Bibliográficos
Autores principales: Hu, Jian, Wille, Holger, Schmitt-Ulms, Gerold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874730/
http://dx.doi.org/10.3390/pathogens7010004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874730/
http://dx.doi.org/10.3390/pathogens7010004

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