Prediction of Drug-Drug Interactions with Bupropion and Its Metabolites as CYP2D6 Inhibitors Using a Physiologically-Based Pharmacokinetic Model

The potential of inhibitory metabolites of perpetrator drugs to contribute to drug-drug interactions (DDIs) is uncommon and underestimated. However, the occurrence of unexpected DDI suggests the potential contribution of metabolites to the observed DDI. The aim of this study was to develop a physiol...

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Detalles Bibliográficos
Autores principales: Xue, Caifu, Zhang, Xunjie, Cai, Weimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874814/
https://www.ncbi.nlm.nih.gov/pubmed/29267251
http://dx.doi.org/10.3390/pharmaceutics10010001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874814/
https://www.ncbi.nlm.nih.gov/pubmed/29267251
http://dx.doi.org/10.3390/pharmaceutics10010001

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