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Regulation of Hepatic UGT2B15 by Methylation in Adults of Asian Descent

The hepatic uridine 5′-diphosphate-glucuronosyl transferases (UGTs) are critical for detoxifying endo- and xenobiotics. Since UGTs are also dynamically responsive to endogenous and exogenous stimuli, we examined whether epigenetic DNA methylation can regulate hepatic UGT expression and differential...

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Detalles Bibliográficos
Autores principales: Oeser, Steffen G., Bingham, Jon-Paul, Collier, Abby C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874819/
https://www.ncbi.nlm.nih.gov/pubmed/29316660
http://dx.doi.org/10.3390/pharmaceutics10010006