Cargando…

Preventing Crystal Agglomeration of Pharmaceutical Crystals Using Temperature Cycling and a Novel Membrane Crystallization Procedure for Seed Crystal Generation

In this work, a novel membrane crystallization system was used to crystallize micro-sized seeds of piroxicam monohydrate by reverse antisolvent addition. Membrane crystallization seeds were compared with seeds produced by conventional antisolvent addition and polymorphic transformation of a fine pow...

Descripción completa

Detalles Bibliográficos
Autores principales: Simone, Elena, Othman, Rahimah, Vladisavljević, Goran T., Nagy, Zoltan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874830/
https://www.ncbi.nlm.nih.gov/pubmed/29364167
http://dx.doi.org/10.3390/pharmaceutics10010017
_version_ 1783310240719044608
author Simone, Elena
Othman, Rahimah
Vladisavljević, Goran T.
Nagy, Zoltan K.
author_facet Simone, Elena
Othman, Rahimah
Vladisavljević, Goran T.
Nagy, Zoltan K.
author_sort Simone, Elena
collection PubMed
description In this work, a novel membrane crystallization system was used to crystallize micro-sized seeds of piroxicam monohydrate by reverse antisolvent addition. Membrane crystallization seeds were compared with seeds produced by conventional antisolvent addition and polymorphic transformation of a fine powdered sample of piroxicam form I in water. The membrane crystallization process allowed for a consistent production of pure monohydrate crystals with narrow size distribution and without significant agglomeration. The seeds were grown in 350 g of 20:80 w/w acetone-water mixture. Different seeding loads were tested and temperature cycling was applied in order to avoid agglomeration of the growing crystals during the process. Focused beam reflectance measurement (FBRM); and particle vision and measurement (PVM) were used to monitor crystal growth; nucleation and agglomeration during the seeded experiments. Furthermore; Raman spectroscopy was used to monitor solute concentration and estimate the overall yield of the process. Membrane crystallization was proved to be the most convenient and consistent method to produce seeds of highly agglomerating compounds; which can be grown via cooling crystallization and temperature cycling.
format Online
Article
Text
id pubmed-5874830
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-58748302018-04-02 Preventing Crystal Agglomeration of Pharmaceutical Crystals Using Temperature Cycling and a Novel Membrane Crystallization Procedure for Seed Crystal Generation Simone, Elena Othman, Rahimah Vladisavljević, Goran T. Nagy, Zoltan K. Pharmaceutics Article In this work, a novel membrane crystallization system was used to crystallize micro-sized seeds of piroxicam monohydrate by reverse antisolvent addition. Membrane crystallization seeds were compared with seeds produced by conventional antisolvent addition and polymorphic transformation of a fine powdered sample of piroxicam form I in water. The membrane crystallization process allowed for a consistent production of pure monohydrate crystals with narrow size distribution and without significant agglomeration. The seeds were grown in 350 g of 20:80 w/w acetone-water mixture. Different seeding loads were tested and temperature cycling was applied in order to avoid agglomeration of the growing crystals during the process. Focused beam reflectance measurement (FBRM); and particle vision and measurement (PVM) were used to monitor crystal growth; nucleation and agglomeration during the seeded experiments. Furthermore; Raman spectroscopy was used to monitor solute concentration and estimate the overall yield of the process. Membrane crystallization was proved to be the most convenient and consistent method to produce seeds of highly agglomerating compounds; which can be grown via cooling crystallization and temperature cycling. MDPI 2018-01-24 /pmc/articles/PMC5874830/ /pubmed/29364167 http://dx.doi.org/10.3390/pharmaceutics10010017 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Simone, Elena
Othman, Rahimah
Vladisavljević, Goran T.
Nagy, Zoltan K.
Preventing Crystal Agglomeration of Pharmaceutical Crystals Using Temperature Cycling and a Novel Membrane Crystallization Procedure for Seed Crystal Generation
title Preventing Crystal Agglomeration of Pharmaceutical Crystals Using Temperature Cycling and a Novel Membrane Crystallization Procedure for Seed Crystal Generation
title_full Preventing Crystal Agglomeration of Pharmaceutical Crystals Using Temperature Cycling and a Novel Membrane Crystallization Procedure for Seed Crystal Generation
title_fullStr Preventing Crystal Agglomeration of Pharmaceutical Crystals Using Temperature Cycling and a Novel Membrane Crystallization Procedure for Seed Crystal Generation
title_full_unstemmed Preventing Crystal Agglomeration of Pharmaceutical Crystals Using Temperature Cycling and a Novel Membrane Crystallization Procedure for Seed Crystal Generation
title_short Preventing Crystal Agglomeration of Pharmaceutical Crystals Using Temperature Cycling and a Novel Membrane Crystallization Procedure for Seed Crystal Generation
title_sort preventing crystal agglomeration of pharmaceutical crystals using temperature cycling and a novel membrane crystallization procedure for seed crystal generation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874830/
https://www.ncbi.nlm.nih.gov/pubmed/29364167
http://dx.doi.org/10.3390/pharmaceutics10010017
work_keys_str_mv AT simoneelena preventingcrystalagglomerationofpharmaceuticalcrystalsusingtemperaturecyclingandanovelmembranecrystallizationprocedureforseedcrystalgeneration
AT othmanrahimah preventingcrystalagglomerationofpharmaceuticalcrystalsusingtemperaturecyclingandanovelmembranecrystallizationprocedureforseedcrystalgeneration
AT vladisavljevicgorant preventingcrystalagglomerationofpharmaceuticalcrystalsusingtemperaturecyclingandanovelmembranecrystallizationprocedureforseedcrystalgeneration
AT nagyzoltank preventingcrystalagglomerationofpharmaceuticalcrystalsusingtemperaturecyclingandanovelmembranecrystallizationprocedureforseedcrystalgeneration