Prediction of Phase Behavior of Spray-Dried Amorphous Solid Dispersions: Assessment of Thermodynamic Models, Standard Screening Methods and a Novel Atomization Screening Device with Regard to Prediction Accuracy

The evaluation of drug–polymer miscibility in the early phase of drug development is essential to ensure successful amorphous solid dispersion (ASD) manufacturing. This work investigates the comparison of thermodynamic models, conventional experimental screening methods (solvent casting, quench cool...

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Detalles Bibliográficos
Autores principales: Ousset, Aymeric, Chavez, Pierre-François, Meeus, Joke, Robin, Florent, Schubert, Martin Alexander, Somville, Pascal, Dodou, Kalliopi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874842/
https://www.ncbi.nlm.nih.gov/pubmed/29518936
http://dx.doi.org/10.3390/pharmaceutics10010029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874842/
https://www.ncbi.nlm.nih.gov/pubmed/29518936
http://dx.doi.org/10.3390/pharmaceutics10010029

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