Orally Disintegrating Tablets Containing Melt Extruded Amorphous Solid Dispersion of Tacrolimus for Dissolution Enhancement

In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus(®) and Hydroxypropyl Cellulose (HPC), at a drug loading of 1...

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Detalles Bibliográficos
Autores principales: Ponnammal, Poovizhi, Kanaujia, Parijat, Yani, Yin, Ng, Wai Kiong, Tan, Reginald B. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874848/
https://www.ncbi.nlm.nih.gov/pubmed/29547585
http://dx.doi.org/10.3390/pharmaceutics10010035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874848/
https://www.ncbi.nlm.nih.gov/pubmed/29547585
http://dx.doi.org/10.3390/pharmaceutics10010035

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