Bioengineering of rFVIIa Biopharmaceutical and Structure Characterization for Biosimilarity Assessment

Eptacog alfa (NovoSeven(®)) is a vitamin K-dependent recombinant Factor VIIa produced by genetic engineering from baby hamster kidney (BHK) cells as a single peptide chain of 406 residues. After activation, it consists of a light chain (LC) of 152 amino and a heavy chain (HC) of 254 amino acids. Rec...

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Detalles Bibliográficos
Autores principales: Montacir, Othman, Montacir, Houda, Eravci, Murat, Springer, Andreas, Hinderlich, Stephan, Mahboudi, Fereidoun, Saadati, Amirhossein, Parr, Maria Kristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874873/
https://www.ncbi.nlm.nih.gov/pubmed/29351237
http://dx.doi.org/10.3390/bioengineering5010007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874873/
https://www.ncbi.nlm.nih.gov/pubmed/29351237
http://dx.doi.org/10.3390/bioengineering5010007

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