Cystic Kidney Diseases From the Adult Nephrologist’s Point of View

Cystic kidney diseases affect patients of all age groups with the onset spanning from prenatal disease to late adulthood. Autosomal-dominant polycystic kidney disease (ADPKD) is by far the most common renal cystic disease. However, there are various cystic kidney diseases, the onset of which occurs...

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Autores principales: Müller, Roman-Ulrich, Benzing, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875104/
https://www.ncbi.nlm.nih.gov/pubmed/29623269
http://dx.doi.org/10.3389/fped.2018.00065
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author Müller, Roman-Ulrich
Benzing, Thomas
author_facet Müller, Roman-Ulrich
Benzing, Thomas
author_sort Müller, Roman-Ulrich
collection PubMed
description Cystic kidney diseases affect patients of all age groups with the onset spanning from prenatal disease to late adulthood. Autosomal-dominant polycystic kidney disease (ADPKD) is by far the most common renal cystic disease. However, there are various cystic kidney diseases, the onset of which occurs at different times in life and depends on the type of the disease and the causative genes involved. When genetic kidney diseases are discussed in the adult setting this view is usually limited on autosomal-dominant kidney disease, the most frequent genetic disorder causing adult onset ESRD. Other diseases—such as autosomal-recessive polycystic kidney disease—are often being viewed as a disorder only important in pediatric nephrology. However, more recent data has revealed that, despite clear age peaks of onset for each disorder, all of them can also show highly variable phenotypes with classical adult onset genetic diseases being of importance in pediatrics and vice versa. Furthermore, the affected children need to be seen by adult nephrologists in the long term after transition, requiring knowledge on the underlying pediatric disease, potential extrarenal manifestations, and genetic counseling. Consequently, the view on these diseases should be widened on both ends. Close interaction between pediatric and adult nephrology is key to appropriate care of patients suffering from genetic kidney disease to profit from each other’s experience.
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spelling pubmed-58751042018-04-05 Cystic Kidney Diseases From the Adult Nephrologist’s Point of View Müller, Roman-Ulrich Benzing, Thomas Front Pediatr Pediatrics Cystic kidney diseases affect patients of all age groups with the onset spanning from prenatal disease to late adulthood. Autosomal-dominant polycystic kidney disease (ADPKD) is by far the most common renal cystic disease. However, there are various cystic kidney diseases, the onset of which occurs at different times in life and depends on the type of the disease and the causative genes involved. When genetic kidney diseases are discussed in the adult setting this view is usually limited on autosomal-dominant kidney disease, the most frequent genetic disorder causing adult onset ESRD. Other diseases—such as autosomal-recessive polycystic kidney disease—are often being viewed as a disorder only important in pediatric nephrology. However, more recent data has revealed that, despite clear age peaks of onset for each disorder, all of them can also show highly variable phenotypes with classical adult onset genetic diseases being of importance in pediatrics and vice versa. Furthermore, the affected children need to be seen by adult nephrologists in the long term after transition, requiring knowledge on the underlying pediatric disease, potential extrarenal manifestations, and genetic counseling. Consequently, the view on these diseases should be widened on both ends. Close interaction between pediatric and adult nephrology is key to appropriate care of patients suffering from genetic kidney disease to profit from each other’s experience. Frontiers Media S.A. 2018-03-22 /pmc/articles/PMC5875104/ /pubmed/29623269 http://dx.doi.org/10.3389/fped.2018.00065 Text en Copyright © 2018 Müller and Benzing. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Müller, Roman-Ulrich
Benzing, Thomas
Cystic Kidney Diseases From the Adult Nephrologist’s Point of View
title Cystic Kidney Diseases From the Adult Nephrologist’s Point of View
title_full Cystic Kidney Diseases From the Adult Nephrologist’s Point of View
title_fullStr Cystic Kidney Diseases From the Adult Nephrologist’s Point of View
title_full_unstemmed Cystic Kidney Diseases From the Adult Nephrologist’s Point of View
title_short Cystic Kidney Diseases From the Adult Nephrologist’s Point of View
title_sort cystic kidney diseases from the adult nephrologist’s point of view
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875104/
https://www.ncbi.nlm.nih.gov/pubmed/29623269
http://dx.doi.org/10.3389/fped.2018.00065
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