Uromodulin deficiency alters tubular injury and interstitial inflammation but not fibrosis in experimental obstructive nephropathy

Human GWAS and Mendelian genetic studies have linked polymorphic variants and mutations in the human uromodulin gene (UMOD) with chronic kidney disease. The primary function of this kidney‐specific and secreted protein remains elusive. This study investigated whether UMOD deficiency modified respons...

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Detalles Bibliográficos
Autores principales: Maydan, Olena, McDade, Paul G., Liu, Yan, Wu, Xue‐Ru, Matsell, Douglas G., Eddy, Allison A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875544/
https://www.ncbi.nlm.nih.gov/pubmed/29595914
http://dx.doi.org/10.14814/phy2.13654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875544/
https://www.ncbi.nlm.nih.gov/pubmed/29595914
http://dx.doi.org/10.14814/phy2.13654

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