Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells

Apaf1 is a critical component of the apoptosome and initiates apoptosis downstream mitochondrial damages. Although the importance of Apaf1 in embryonic development was shown, the role of Apaf1 in immune responses, especially T cell responses, has yet to be elucidated. We generated T cell-specific Ap...

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Detalles Bibliográficos
Autores principales: Tong, Honglian, Miyake, Yasunobu, Mi-ichi, Fumika, Iwakura, Yoichiro, Hara, Hiromitsu, Yoshida, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875858/
https://www.ncbi.nlm.nih.gov/pubmed/29596528
http://dx.doi.org/10.1371/journal.pone.0195119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875858/
https://www.ncbi.nlm.nih.gov/pubmed/29596528
http://dx.doi.org/10.1371/journal.pone.0195119

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