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Apaf1 plays a negative regulatory role in T cell responses by suppressing activation of antigen-stimulated T cells
Apaf1 is a critical component of the apoptosome and initiates apoptosis downstream mitochondrial damages. Although the importance of Apaf1 in embryonic development was shown, the role of Apaf1 in immune responses, especially T cell responses, has yet to be elucidated. We generated T cell-specific Ap...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875858/ https://www.ncbi.nlm.nih.gov/pubmed/29596528 http://dx.doi.org/10.1371/journal.pone.0195119 |