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Developmentally primed cortical neurons maintain fidelity of differentiation and establish appropriate functional connectivity after transplantation
Repair of complex CNS circuitry will require newly incorporated neurons to become appropriately, functionally integrated. One approach is to direct differentiation of endogenous progenitors in situ, or ex vivo followed by transplantation. Prior studies find that newly incorporated neurons can establ...
Autores principales: | Wuttke, Thomas V., Markopoulos, Foivos, Padmanabhan, Hari, Wheeler, Aaron P., Murthy, Venkatesh N., Macklis, Jeffrey D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876138/ https://www.ncbi.nlm.nih.gov/pubmed/29507412 http://dx.doi.org/10.1038/s41593-018-0098-0 |
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