Social Deficits in Shank3-deficient Mouse Models of Autism Are Rescued by histone deacetylase (HDAC) Inhibition

Haploinsufficiency of the SHANK3 gene is causally linked to autism spectrum disorder (ASD), and ASD-associated genes are also enriched for chromatin remodelers. Here, we found that brief treatment with romidepsin, a highly potent class I histone deacetylase (HDAC) inhibitor, alleviated social defici...

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Detalles Bibliográficos
Autores principales: Qin, Luye, Ma, Kaijie, Wang, Zi-Jun, Hu, Zihua, Matas, Emmanuel, Wei, Jing, Yan, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876144/
https://www.ncbi.nlm.nih.gov/pubmed/29531362
http://dx.doi.org/10.1038/s41593-018-0110-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876144/
https://www.ncbi.nlm.nih.gov/pubmed/29531362
http://dx.doi.org/10.1038/s41593-018-0110-8

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