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Social Deficits in Shank3-deficient Mouse Models of Autism Are Rescued by histone deacetylase (HDAC) Inhibition
Haploinsufficiency of the SHANK3 gene is causally linked to autism spectrum disorder (ASD), and ASD-associated genes are also enriched for chromatin remodelers. Here, we found that brief treatment with romidepsin, a highly potent class I histone deacetylase (HDAC) inhibitor, alleviated social defici...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876144/ https://www.ncbi.nlm.nih.gov/pubmed/29531362 http://dx.doi.org/10.1038/s41593-018-0110-8 |