Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation

Acute myeloid leukemia (AML) remains the most common form of acute leukemia among adults and accounts for a large number of leukemia-related deaths. Mutations in FMS-like tyrosine kinase 3 (FLT3) is one of the most prevalent findings in this heterogeneous disease. The major types of mutations in FLT...

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Detalles Bibliográficos
Autores principales: Marhäll, Alissa, Heidel, Florian, Fischer, Thomas, Rönnstrand, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876274/
https://www.ncbi.nlm.nih.gov/pubmed/29372308
http://dx.doi.org/10.1007/s00277-018-3245-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876274/
https://www.ncbi.nlm.nih.gov/pubmed/29372308
http://dx.doi.org/10.1007/s00277-018-3245-5

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