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The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair

EXD2 is a recently identified exonuclease that has been implicated in nuclear double-strand break repair. Given our long standing interest in mitochondrial DNA maintenance and indications that EXD2 could also be a mitochondrial protein we sought to determine its cellular localization and possible mi...

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Detalles Bibliográficos
Autores principales: Hensen, Fenna, Moretton, Amandine, van Esveld, Selma, Farge, Géraldine, Spelbrink, Johannes N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876329/
https://www.ncbi.nlm.nih.gov/pubmed/29599527
http://dx.doi.org/10.1038/s41598-018-23690-y