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Multilocus genetic profile in dopaminergic pathway modulates the striatum and working memory

Dopamine is critical in pathophysiology and therapy of schizophrenia. Many studies have reported altered dopaminergic activity in the dorsal but not ventral striatum in schizophrenia. Based on the largest genome-wide association study of schizophrenia to date, we calculated the polygenic risk score...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Liu, Bing, Zhang, Xiaolong, Cui, Yue, Yu, Chunshui, Jiang, Tianzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876382/
https://www.ncbi.nlm.nih.gov/pubmed/29599495
http://dx.doi.org/10.1038/s41598-018-23191-y