The Notch inhibitor cowanin accelerates nicastrin degradation

Aberrant activation of Notch signaling contributes to the pathogenesis of several different types of cancer, and Notch pathway inhibitors may have significant therapeutic potential. Using a unique cell-based assay system, we isolated twelve compounds, including one new natural product from Garcinia...

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Detalles Bibliográficos
Autores principales: Arai, Midori A., Akamine, Ryuta, Tsuchiya, Anna, Yoneyama, Tatsuro, Koyano, Takashi, Kowithayakorn, Thaworn, Ishibashi, Masami
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876388/
https://www.ncbi.nlm.nih.gov/pubmed/29599482
http://dx.doi.org/10.1038/s41598-018-23698-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876388/
https://www.ncbi.nlm.nih.gov/pubmed/29599482
http://dx.doi.org/10.1038/s41598-018-23698-4

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