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Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults

Nicotinamide adenine dinucleotide (NAD(+)) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan. As such, the use of NAD(+) precursors to augment NAD(+) bioavailability has been proposed as a strategy for improving cardiov...

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Autores principales: Martens, Christopher R., Denman, Blair A., Mazzo, Melissa R., Armstrong, Michael L., Reisdorph, Nichole, McQueen, Matthew B., Chonchol, Michel, Seals, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876407/
https://www.ncbi.nlm.nih.gov/pubmed/29599478
http://dx.doi.org/10.1038/s41467-018-03421-7
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author Martens, Christopher R.
Denman, Blair A.
Mazzo, Melissa R.
Armstrong, Michael L.
Reisdorph, Nichole
McQueen, Matthew B.
Chonchol, Michel
Seals, Douglas R.
author_facet Martens, Christopher R.
Denman, Blair A.
Mazzo, Melissa R.
Armstrong, Michael L.
Reisdorph, Nichole
McQueen, Matthew B.
Chonchol, Michel
Seals, Douglas R.
author_sort Martens, Christopher R.
collection PubMed
description Nicotinamide adenine dinucleotide (NAD(+)) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan. As such, the use of NAD(+) precursors to augment NAD(+) bioavailability has been proposed as a strategy for improving cardiovascular and other physiological functions with aging in humans. Here we provide the evidence in a 2 × 6-week randomized, double-blind, placebo-controlled, crossover clinical trial that chronic supplementation with the NAD(+) precursor vitamin, nicotinamide riboside (NR), is well tolerated and effectively stimulates NAD(+) metabolism in healthy middle-aged and older adults. Our results also provide initial insight into the effects of chronic NR supplementation on physiological function in humans, and suggest that, in particular, future clinical trials should further assess the potential benefits of NR for reducing blood pressure and arterial stiffness in this group.
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spelling pubmed-58764072018-04-02 Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults Martens, Christopher R. Denman, Blair A. Mazzo, Melissa R. Armstrong, Michael L. Reisdorph, Nichole McQueen, Matthew B. Chonchol, Michel Seals, Douglas R. Nat Commun Article Nicotinamide adenine dinucleotide (NAD(+)) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan. As such, the use of NAD(+) precursors to augment NAD(+) bioavailability has been proposed as a strategy for improving cardiovascular and other physiological functions with aging in humans. Here we provide the evidence in a 2 × 6-week randomized, double-blind, placebo-controlled, crossover clinical trial that chronic supplementation with the NAD(+) precursor vitamin, nicotinamide riboside (NR), is well tolerated and effectively stimulates NAD(+) metabolism in healthy middle-aged and older adults. Our results also provide initial insight into the effects of chronic NR supplementation on physiological function in humans, and suggest that, in particular, future clinical trials should further assess the potential benefits of NR for reducing blood pressure and arterial stiffness in this group. Nature Publishing Group UK 2018-03-29 /pmc/articles/PMC5876407/ /pubmed/29599478 http://dx.doi.org/10.1038/s41467-018-03421-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Martens, Christopher R.
Denman, Blair A.
Mazzo, Melissa R.
Armstrong, Michael L.
Reisdorph, Nichole
McQueen, Matthew B.
Chonchol, Michel
Seals, Douglas R.
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults
title Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults
title_full Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults
title_fullStr Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults
title_full_unstemmed Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults
title_short Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults
title_sort chronic nicotinamide riboside supplementation is well-tolerated and elevates nad(+) in healthy middle-aged and older adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876407/
https://www.ncbi.nlm.nih.gov/pubmed/29599478
http://dx.doi.org/10.1038/s41467-018-03421-7
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