Role and inhibition of GLI1 protein in cancer

GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. Exp...

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Detalles Bibliográficos
Autores principales: Mastrangelo, Eloise, Milani, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877502/
https://www.ncbi.nlm.nih.gov/pubmed/29628779
http://dx.doi.org/10.2147/LCTT.S124483
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author Mastrangelo, Eloise
Milani, Mario
author_facet Mastrangelo, Eloise
Milani, Mario
author_sort Mastrangelo, Eloise
collection PubMed
description GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. Experimental evidences show GLI1 involvement in both small- and non–small-cell lung cancers. Direct inhibition of the protein, in combination with other chemotherapeutic agents, represents a promising strategy for the treatment of different malignancies.
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spelling pubmed-58775022018-04-06 Role and inhibition of GLI1 protein in cancer Mastrangelo, Eloise Milani, Mario Lung Cancer (Auckl) Review GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. Experimental evidences show GLI1 involvement in both small- and non–small-cell lung cancers. Direct inhibition of the protein, in combination with other chemotherapeutic agents, represents a promising strategy for the treatment of different malignancies. Dove Medical Press 2018-03-27 /pmc/articles/PMC5877502/ /pubmed/29628779 http://dx.doi.org/10.2147/LCTT.S124483 Text en © 2018 Mastrangelo and Milani. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Review
Mastrangelo, Eloise
Milani, Mario
Role and inhibition of GLI1 protein in cancer
title Role and inhibition of GLI1 protein in cancer
title_full Role and inhibition of GLI1 protein in cancer
title_fullStr Role and inhibition of GLI1 protein in cancer
title_full_unstemmed Role and inhibition of GLI1 protein in cancer
title_short Role and inhibition of GLI1 protein in cancer
title_sort role and inhibition of gli1 protein in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877502/
https://www.ncbi.nlm.nih.gov/pubmed/29628779
http://dx.doi.org/10.2147/LCTT.S124483
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