Cys Site-Directed Mutagenesis of the Human SLC1A5 (ASCT2) Transporter: Structure/Function Relationships and Crucial Role of Cys467 for Redox Sensing and Glutamine Transport

The human plasma membrane transporter ASCT2 is responsible for mediating Na- dependent antiport of neutral amino acids. New insights into structure/function relationships were unveiled by a combined approach of recombinant over-expression, site-directed mutagenesis, transport assays in proteoliposom...

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Detalles Bibliográficos
Autores principales: Scalise, Mariafrancesca, Pochini, Lorena, Console, Lara, Pappacoda, Gilda, Pingitore, Piero, Hedfalk, Kristina, Indiveri, Cesare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877509/
https://www.ncbi.nlm.nih.gov/pubmed/29495336
http://dx.doi.org/10.3390/ijms19030648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877509/
https://www.ncbi.nlm.nih.gov/pubmed/29495336
http://dx.doi.org/10.3390/ijms19030648

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