EP4 Agonist L-902,688 Suppresses EndMT and Attenuates Right Ventricular Cardiac Fibrosis in Experimental Pulmonary Arterial Hypertension

Right ventricular (RV) hypertrophy is characterized by cardiac fibrosis due to endothelial–mesenchymal transition (EndMT) and increased collagen production in pulmonary arterial hypertension (PAH) patients, but the mechanisms for restoring RV function are unclear. Prostanoid agonists are effective v...

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Detalles Bibliográficos
Autores principales: Lai, Ying-Ju, Chen, I-Chen, Li, Hsin-Hsien, Huang, Chung-Chi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877588/
https://www.ncbi.nlm.nih.gov/pubmed/29510514
http://dx.doi.org/10.3390/ijms19030727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877588/
https://www.ncbi.nlm.nih.gov/pubmed/29510514
http://dx.doi.org/10.3390/ijms19030727

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