Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity

Sarcopenia and sarcopenic obesity are currently considered major global threats for health and well-being. However, there is a lack of adequate preclinical models for their study. The present trial evaluated the suitability of aged swine by determining changes in adiposity, fatty acids composition,...

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Autores principales: Garcia-Contreras, Consolacion, Vazquez-Gomez, Marta, Torres-Rovira, Laura, Gonzalez, Jorge, Porrini, Esteban, Gonzalez-Colaço, Magali, Isabel, Beatriz, Astiz, Susana, Gonzalez-Bulnes, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877684/
https://www.ncbi.nlm.nih.gov/pubmed/29534532
http://dx.doi.org/10.3390/ijms19030823
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author Garcia-Contreras, Consolacion
Vazquez-Gomez, Marta
Torres-Rovira, Laura
Gonzalez, Jorge
Porrini, Esteban
Gonzalez-Colaço, Magali
Isabel, Beatriz
Astiz, Susana
Gonzalez-Bulnes, Antonio
author_facet Garcia-Contreras, Consolacion
Vazquez-Gomez, Marta
Torres-Rovira, Laura
Gonzalez, Jorge
Porrini, Esteban
Gonzalez-Colaço, Magali
Isabel, Beatriz
Astiz, Susana
Gonzalez-Bulnes, Antonio
author_sort Garcia-Contreras, Consolacion
collection PubMed
description Sarcopenia and sarcopenic obesity are currently considered major global threats for health and well-being. However, there is a lack of adequate preclinical models for their study. The present trial evaluated the suitability of aged swine by determining changes in adiposity, fatty acids composition, antioxidant status and lipid peroxidation, development of metabolic disturbances and structural changes in tissues and organs. Iberian sows with clinical evidence of aging-related sarcopenia were fed a standard diet fulfilling their maintenance requirements or an obesogenic diet for 100 days. Aging and sarcopenia were related to increased lipid accumulation and cellular dysfunction at both adipose tissue and non-adipose ectopic tissues (liver and pancreas). Obesity concomitant to sarcopenia aggravates the condition by increasing visceral adiposity and causing dyslipidemia, insulin resistance and lipotoxicity in non-adipose tissues. These results support that the Iberian swine model represents certain features of sarcopenia and sarcopenic obesity in humans, paving the way for future research on physiopathology of these conditions and possible therapeutic targets.
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spelling pubmed-58776842018-04-09 Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity Garcia-Contreras, Consolacion Vazquez-Gomez, Marta Torres-Rovira, Laura Gonzalez, Jorge Porrini, Esteban Gonzalez-Colaço, Magali Isabel, Beatriz Astiz, Susana Gonzalez-Bulnes, Antonio Int J Mol Sci Article Sarcopenia and sarcopenic obesity are currently considered major global threats for health and well-being. However, there is a lack of adequate preclinical models for their study. The present trial evaluated the suitability of aged swine by determining changes in adiposity, fatty acids composition, antioxidant status and lipid peroxidation, development of metabolic disturbances and structural changes in tissues and organs. Iberian sows with clinical evidence of aging-related sarcopenia were fed a standard diet fulfilling their maintenance requirements or an obesogenic diet for 100 days. Aging and sarcopenia were related to increased lipid accumulation and cellular dysfunction at both adipose tissue and non-adipose ectopic tissues (liver and pancreas). Obesity concomitant to sarcopenia aggravates the condition by increasing visceral adiposity and causing dyslipidemia, insulin resistance and lipotoxicity in non-adipose tissues. These results support that the Iberian swine model represents certain features of sarcopenia and sarcopenic obesity in humans, paving the way for future research on physiopathology of these conditions and possible therapeutic targets. MDPI 2018-03-12 /pmc/articles/PMC5877684/ /pubmed/29534532 http://dx.doi.org/10.3390/ijms19030823 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Garcia-Contreras, Consolacion
Vazquez-Gomez, Marta
Torres-Rovira, Laura
Gonzalez, Jorge
Porrini, Esteban
Gonzalez-Colaço, Magali
Isabel, Beatriz
Astiz, Susana
Gonzalez-Bulnes, Antonio
Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity
title Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity
title_full Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity
title_fullStr Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity
title_full_unstemmed Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity
title_short Characterization of Ageing- and Diet-Related Swine Models of Sarcopenia and Sarcopenic Obesity
title_sort characterization of ageing- and diet-related swine models of sarcopenia and sarcopenic obesity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877684/
https://www.ncbi.nlm.nih.gov/pubmed/29534532
http://dx.doi.org/10.3390/ijms19030823
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