The Amino-Terminal Domain of GRK5 Inhibits Cardiac Hypertrophy through the Regulation of Calcium-Calmodulin Dependent Transcription Factors

We have recently demonstrated that the amino-terminal domain of G protein coupled receptor kinase (GRK) type 5, (GRK5-NT) inhibits NFκB activity in cardiac cells leading to a significant amelioration of LVH. Since GRK5-NT is known to bind calmodulin, this study aimed to evaluate the functional role...

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Detalles Bibliográficos
Autores principales: Sorriento, Daniela, Santulli, Gaetano, Ciccarelli, Michele, Maione, Angela Serena, Illario, Maddalena, Trimarco, Bruno, Iaccarino, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877722/
https://www.ncbi.nlm.nih.gov/pubmed/29543709
http://dx.doi.org/10.3390/ijms19030861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877722/
https://www.ncbi.nlm.nih.gov/pubmed/29543709
http://dx.doi.org/10.3390/ijms19030861

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