Prediction of Tacrolimus Exposure by CYP3A5 Genotype and Exposure of Co-Administered Everolimus in Japanese Renal Transplant Recipients

While tacrolimus and everolimus have common metabolic pathways through CYP3A4/5, tacrolimus is metabolized solely by CYP3A4 in recipients with the CYP3A5*3/*3. The purpose of this study was to evaluate how the area under the blood concentration-time curves (AUC) of tacrolimus could be predicted base...

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Detalles Bibliográficos
Autores principales: Kagaya, Hideaki, Niioka, Takenori, Saito, Mitsuru, Inoue, Takamitsu, Numakura, Kazuyuki, Yamamoto, Ryohei, Akamine, Yumiko, Habuchi, Tomonori, Satoh, Shigeru, Miura, Masatomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877743/
https://www.ncbi.nlm.nih.gov/pubmed/29547545
http://dx.doi.org/10.3390/ijms19030882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877743/
https://www.ncbi.nlm.nih.gov/pubmed/29547545
http://dx.doi.org/10.3390/ijms19030882

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