A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells

Accumulation of lipofuscin in the retinal pigmented epithelium (RPE) is observed in retinal degenerative diseases including Stargardt disease and age-related macular degeneration. Bis-retinoid N-retinyl-N-retinylidene ethanolamine (A2E) is a major component of lipofuscin. A2E has been implicated in...

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Detalles Bibliográficos
Autores principales: Parmar, Vipul M., Parmar, Tanu, Arai, Eisuke, Perusek, Lindsay, Maeda, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877810/
https://www.ncbi.nlm.nih.gov/pubmed/29358124
http://dx.doi.org/10.1016/j.scr.2018.01.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877810/
https://www.ncbi.nlm.nih.gov/pubmed/29358124
http://dx.doi.org/10.1016/j.scr.2018.01.014

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