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Structure of full-length human TRPM4

Transient receptor potential melastatin subfamily member 4 (TRPM4) is a widely distributed, calcium-activated, monovalent-selective cation channel. Mutations in human TRPM4 (hTRPM4) result in progressive familial heart block. Here, we report the electron cryomicroscopy structure of hTRPM4 in a close...

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Detalles Bibliográficos
Autores principales: Duan, Jingjing, Li, Zongli, Li, Jian, Santa-Cruz, Ana, Sanchez-Martinez, Silvia, Zhang, Jin, Clapham, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877947/
https://www.ncbi.nlm.nih.gov/pubmed/29463718
http://dx.doi.org/10.1073/pnas.1722038115