MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice

Autoimmune type 1 diabetes (T1D) and other autoimmune diseases are associated with particular MHC haplotypes and expansion of autoreactive T cells. Induction of MHC-mismatched but not -matched mixed chimerism by hematopoietic cell transplantation effectively reverses autoimmunity in diabetic nonobes...

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Detalles Bibliográficos
Autores principales: Zhang, Mingfeng, Racine, Jeremy J., Lin, Qing, Liu, Yuqing, Tang, Shanshan, Qin, Qi, Qi, Tong, Riggs, Arthur D., Zeng, Defu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877958/
https://www.ncbi.nlm.nih.gov/pubmed/29463744
http://dx.doi.org/10.1073/pnas.1720169115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877958/
https://www.ncbi.nlm.nih.gov/pubmed/29463744
http://dx.doi.org/10.1073/pnas.1720169115

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