G(i)- and G(s)-coupled GPCRs show different modes of G-protein binding

More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered. Upon light-induced changes in ligand–receptor interaction, movement of specific transmembrane helices within the receptor opens a crevi...

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Detalles Bibliográficos
Autores principales: Van Eps, Ned, Altenbach, Christian, Caro, Lydia N., Latorraca, Naomi R., Hollingsworth, Scott A., Dror, Ron O., Ernst, Oliver P., Hubbell, Wayne L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877964/
https://www.ncbi.nlm.nih.gov/pubmed/29463720
http://dx.doi.org/10.1073/pnas.1721896115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877964/
https://www.ncbi.nlm.nih.gov/pubmed/29463720
http://dx.doi.org/10.1073/pnas.1721896115

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