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Oxidized phospholipids stimulate production of stem cell factor via NRF2-dependent mechanisms

Receptor tyrosine kinase c-Kit and its ligand stem cell factor (SCF) regulate resident vascular wall cells and recruit circulating progenitors. We tested whether SCF may be induced by oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) known to accumulate in atherosclerotic vessels. Gene ex...

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Detalles Bibliográficos
Autores principales: Afonyushkin, Taras, Oskolkova, Olga V., Bochkov, Valery N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878191/
https://www.ncbi.nlm.nih.gov/pubmed/29330760
http://dx.doi.org/10.1007/s10456-017-9590-5