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Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis
Corneal neovascularization is a sight-threatening condition caused by angiogenesis in the normally avascular cornea. Neovascularization of the cornea is often associated with an inflammatory response, thus targeting VEGF-A alone yields only a limited efficacy. The NF-κB signaling pathway plays impor...
Autores principales: | Lennikov, Anton, Mirabelli, Pierfrancesco, Mukwaya, Anthony, Schaupper, Mira, Thangavelu, Muthukumar, Lachota, Mieszko, Ali, Zaheer, Jensen, Lasse, Lagali, Neil |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878206/ https://www.ncbi.nlm.nih.gov/pubmed/29332242 http://dx.doi.org/10.1007/s10456-018-9594-9 |
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