Antiretroviral Drug Metabolism in Humanized PXR-CAR-CYP3A-NOG Mice

Antiretroviral drug (ARV) metabolism is linked largely to hepatic cytochrome P450 activity. One ARV drug class known to be metabolized by intestinal and hepatic CYP3A are the protease inhibitors (PIs). Plasma drug concentrations are boosted by CYP3A inhibitors such as cobisistat and ritonavir (RTV)....

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Detalles Bibliográficos
Autores principales: McMillan, JoEllyn M., Cobb, Denise A., Lin, Zhiyi, Banoub, Mary G., Dagur, Raghubendra S., Branch Woods, Amanda A., Wang, Weimin, Makarov, Edward, Kocher, Ted, Joshi, Poonam S., Quadros, Rolen M., Harms, Donald W., Cohen, Samuel M., Gendelman, Howard E., Gurumurthy, Channabasavaiah B., Gorantla, Santhi, Poluektova, Larisa Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2018
Materias:
Metabolism, Transport, and Pharmacogenomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878674/
https://www.ncbi.nlm.nih.gov/pubmed/29476044
http://dx.doi.org/10.1124/jpet.117.247288

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878674/
https://www.ncbi.nlm.nih.gov/pubmed/29476044
http://dx.doi.org/10.1124/jpet.117.247288

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