Uric Acid Impairs Insulin Signaling by Promoting Enpp1 Binding to Insulin Receptor in Human Umbilical Vein Endothelial Cells

High levels of uric acid (UA) are associated with type-2 diabetes and cardiovascular disease. Recent pieces of evidence attributed to UA a causative role in the appearance of diabetes and vascular damage. However, the molecular mechanisms by which UA induces these alterations have not been completel...

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Detalles Bibliográficos
Autores principales: Tassone, Eliezer J., Cimellaro, Antonio, Perticone, Maria, Hribal, Marta L., Sciacqua, Angela, Andreozzi, Francesco, Sesti, Giorgio, Perticone, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879120/
https://www.ncbi.nlm.nih.gov/pubmed/29619007
http://dx.doi.org/10.3389/fendo.2018.00098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879120/
https://www.ncbi.nlm.nih.gov/pubmed/29619007
http://dx.doi.org/10.3389/fendo.2018.00098

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