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Palmitate-induced Slc2a4/GLUT4 downregulation in L6 muscle cells: evidence of inflammatory and endoplasmic reticulum stress involvement

BACKGROUND: Obesity is strongly associated to insulin resistance, inflammation, and elevated plasma free fatty acids, but the mechanisms behind this association are not fully comprehended. Evidences suggest that endoplasmic reticulum (ER) stress may play a role in this complex pathophysiology. The a...

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Detalles Bibliográficos
Autores principales: Ebersbach-Silva, Patrícia, Poletto, Ana Cláudia, David-Silva, Aline, Seraphim, Patrícia Monteiro, Anhê, Gabriel Forato, Passarelli, Marisa, Furuya, Daniela Tomie, Machado, Ubiratan Fabres
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879605/
https://www.ncbi.nlm.nih.gov/pubmed/29609616
http://dx.doi.org/10.1186/s12944-018-0714-8