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Sign of selection on mutation rate modifiers depends on population size

The influence of population size (N) on natural selection acting on alleles that affect fitness has been understood for almost a century. As N declines, genetic drift overwhelms selection and alleles with direct fitness effects are rendered neutral. Often, however, alleles experience so-called indir...

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Detalles Bibliográficos
Autores principales: Raynes, Yevgeniy, Wylie, C. Scott, Sniegowski, Paul D., Weinreich, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879664/
https://www.ncbi.nlm.nih.gov/pubmed/29531067
http://dx.doi.org/10.1073/pnas.1715996115