Cargando…

Does tranexamic acid lead to changes in MRI measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? Protocol for a MRI substudy nested within the double-blind randomised controlled TICH-2 trial

OBJECTIVES: To test whether administration of the antifibrinolytic drug tranexamic acid (TXA) in patients with spontaneous intracerebral haemorrhage (SICH) leads to increased prevalence of diffusion-weighted MRI-defined hyperintense ischaemic lesions (primary hypothesis) or reduced perihaematomal oe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dineen, Rob A, Pszczolkowski, Stefan, Flaherty, Katie, Law, Zhe K, Morgan, Paul S, Roberts, Ian, Werring, David J, Al-Shahi Salman, Rustam, England, Tim, Bath, Philip M, Sprigg, Nikola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2018
Materias:	Radiology and Imaging
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879748/ https://www.ncbi.nlm.nih.gov/pubmed/29431141 http://dx.doi.org/10.1136/bmjopen-2017-019930

Ejemplares similares

Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial
por: Flaherty, Katie, et al.
Publicado: (2017)

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial
por: Sprigg, Nikola, et al.
Publicado: (2018)

Prevention of haematoma progression by tranexamic acid in intracerebral haemorrhage patients with and without spot sign on admission scan: a statistical analysis plan of a pre-specified sub-study of the TICH-2 trial
por: Ovesen, Christian, et al.
Publicado: (2018)

Outcomes in Antiplatelet‐Associated Intracerebral Hemorrhage in the TICH‐2 Randomized Controlled Trial
por: Law, Zhe Kang, et al.
Publicado: (2021)

Automated segmentation of haematoma and perihaematomal oedema in MRI of acute spontaneous intracerebral haemorrhage
por: Pszczolkowski, Stefan, et al.
Publicado: (2019)

Correction: Does tranexamic acid lead to changes in MRI measures of brain tissue health in patients with spontaneous intracerebral haemorrhage? Protocol for a MRI substudy nested within the double-blind randomised controlled TICH-2 trial
Publicado: (2018)

Predictors and Outcomes of Neurological Deterioration in Intracerebral Hemorrhage: Results from the TICH-2 Randomized Controlled Trial
por: Law, Zhe Kang, et al.
Publicado: (2020)

Effects of blood pressure and tranexamic acid in spontaneous intracerebral haemorrhage: a secondary analysis of a large randomised controlled trial
por: Appleton, Jason Philip, et al.
Publicado: (2023)

Quantitative CT radiomics-based models for prediction of haematoma expansion and poor functional outcome in primary intracerebral haemorrhage
por: Pszczolkowski, Stefan, et al.
Publicado: (2021)

Brief Consent Methods Enable Rapid Enrollment in Acute Stroke Trial: Results From the TICH-2 Randomized Controlled Trial
por: Law, Zhe Kang, et al.
Publicado: (2021)

Noncontrast Computed Tomography Signs as Predictors of Hematoma Expansion, Clinical Outcome, and Response to Tranexamic Acid in Acute Intracerebral Hemorrhage
por: Law, Zhe Kang, et al.
Publicado: (2020)

Acute intracerebral haemorrhage: diagnosis and management
por: McGurgan, Iain J, et al.
Publicado: (2021)

Measures of intracranial compartments in acute intracerebral haemorrhage: data from the Rapid Intervention with Glyceryl Trinitrate in Hypertensive Stroke-2 Trial (RIGHT-2)
por: Krishnan, Kailash, et al.
Publicado: (2022)

Tranexamic Acid for Intracerebral Hemorrhage in Patients on Non-Vitamin K Antagonist Oral Anticoagulants (TICH-NOAC): A Multicenter, Randomized, Placebo-Controlled, Phase 2 Trial
por: Polymeris, Alexandros A., et al.
Publicado: (2023)

Desmopressin for patients with spontaneous intracerebral haemorrhage taking antiplatelet drugs (DASH): a UK-based, phase 2, randomised, placebo-controlled, multicentre feasibility trial
por: Desborough, Michael J R, et al.
Publicado: (2023)

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: statistical analysis plan for a randomised controlled trial
por: Al-Shahi Salman, Rustam, et al.
Publicado: (2019)

The Persisting Burden of Intracerebral Haemorrhage: Can Effective Treatments Be Found?
por: Josephson, Colin B., et al.
Publicado: (2010)

Enlarged perivascular spaces as a marker of underlying arteriopathy in intracerebral haemorrhage: a multicentre MRI cohort study
por: Charidimou, Andreas, et al.
Publicado: (2013)

Activation of Nrf2 to Optimise Immune Responses to Intracerebral Haemorrhage
por: Loan, James J. M., et al.
Publicado: (2022)

Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage
por: Almarzouki, Abeer, et al.
Publicado: (2020)

The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial
por: Al-Shahi Salman, Rustam, et al.
Publicado: (2018)

Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double-blind randomised controlled feasibility trial
por: Desborough, Michael J R, et al.
Publicado: (2020)

An Unusual MRI Appearance of Osseous Metastases
por: Boroda, Konstantin, et al.
Publicado: (2015)

Small vessel disease burden and intracerebral haemorrhage in patients taking oral anticoagulants
por: Seiffge, David J, et al.
Publicado: (2021)

Lipoma Arborescens Where MRI Is a Boon
por: Bora, Nikita, et al.
Publicado: (2023)

Publisher Correction: Sensitivity and specificity of blood-fluid levels for oral anticoagulant-associated intracerebral haemorrhage
por: Almarzouki, Abeer, et al.
Publicado: (2021)

Role of MRI in the Diagnosis of Large Right Adrenal Abscess
por: Stankard, Matthew, et al.
Publicado: (2020)

Image-to-Image Translation for Simplified MRI Muscle Segmentation
por: Gadermayr, Michael, et al.
Publicado: (2021)

Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data
por: Moullaali, Tom J, et al.
Publicado: (2022)

Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC)
por: Moullaali, Tom J, et al.
Publicado: (2019)

MRI in the Diagnosis of Bucket Handle Tears: What Is the Current Situation?
por: Pakdemirli, Emre, et al.
Publicado: (2023)

Confounder-adjusted MRI-based predictors of multiple sclerosis disability
por: Kim, Yujin, et al.
Publicado: (2022)

Performance characteristics of methods for quantifying spontaneous intracerebral haemorrhage: data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial
por: Krishnan, Kailash, et al.
Publicado: (2015)

Prescription of blood pressure lowering treatment after intracerebral haemorrhage: Prospective, population-based cohort study
por: Bonello, Karl, et al.
Publicado: (2020)

Evaluation of MR Spectroscopy and Diffusion-Weighted MRI in Postmenopausal Bone Strength
por: Agrawal, Kanhaiya, et al.
Publicado: (2015)

Role of MRI in Breast Cancer Staging: A Case-Based Review
por: Sharma, Swati, et al.
Publicado: (2021)

Preoperative Prediction of Intracranial Meningioma Grade Using Conventional CT and MRI
por: Amano, Toshiyuki, et al.
Publicado: (2022)

Role of Dynamic 3 Tesla MRI in the Evaluation of Temporomandibular Joint Dysfunction
por: Surolia, Pragya, et al.
Publicado: (2023)

MRI Evaluation of Soft Tissue Tumors and Tumor-Like Lesions of Extremities
por: Goyal, Shreeya, et al.
Publicado: (2023)

Haemorrhagic Pseudotumour Following Metal-on-Metal Hip Replacement
por: Filer, Joshua L, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1sedsg2ppr1dpocbl4ms1av6ut