Cargando…

Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOP–Glaucoma

PURPOSE: To determine if one injection of a sustained release formulation of dorzolamide in biodegradable microparticles (DPP) reduces retinal ganglion cell (RGC) loss in a rat model of glaucoma. METHODS: We injected either DPP or control microparticles intravitreally in rats. Two days later, unilat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pitha, Ian, Kimball, Elizabeth C., Oglesby, Ericka N., Pease, Mary Ellen, Fu, Jie, Schaub, Julie, Kim, Yoo-Chun, Hu, Qi, Hanes, Justin, Quigley, Harry A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879766/ https://www.ncbi.nlm.nih.gov/pubmed/29616152 http://dx.doi.org/10.1167/tvst.7.2.13

Ejemplares similares

Regional Retinal Ganglion Cell Axon Loss in a Murine Glaucoma Model
por: Schaub, Julie A., et al.
Publicado: (2017)

Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma
por: Pitha, Ian, et al.
Publicado: (2018)

Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma
por: Quigley, Harry A., et al.
Publicado: (2015)

Time-Lapse Retinal Ganglion Cell Dendritic Field Degeneration Imaged in Organotypic Retinal Explant Culture
por: Johnson, Thomas V., et al.
Publicado: (2016)

Mice with an induced mutation in collagen 8A2 develop larger eyes and are resistant to retinal ganglion cell damage in an experimental glaucoma model
por: Steinhart, Matthew R., et al.
Publicado: (2012)

Scleral fibroblast response to experimental glaucoma in mice
por: Oglesby, Ericka N., et al.
Publicado: (2016)

Ocular Dorzolamide Nanoliposomes for Prolonged IOP Reduction: in-vitroand in-vivo Evaluation in Rabbits
por: Kouchak, Maryam, et al.
Publicado: (2016)

The role of aquaporin-4 in optic nerve head astrocytes in experimental glaucoma
por: Kimball, Elizabeth, et al.
Publicado: (2021)

Astrocyte responses to experimental glaucoma in mouse optic nerve head
por: Quillen, Sarah, et al.
Publicado: (2020)

Axons of retinal ganglion cells on the optic nerve disc following vessel density correction at different IOP values
por: Lešták, Ján, et al.
Publicado: (2023)

Scleral structural alterations associated with chronic experimental intraocular pressure elevation in mice
por: Cone-Kimball, Elizabeth, et al.
Publicado: (2013)

Ion-Complex Microcrystal Formulation Provides Sustained Delivery of a Multimodal Kinase Inhibitor from the Subconjunctival Space for Protection of Retinal Ganglion Cells
por: Hsueh, Henry T., et al.
Publicado: (2021)

Genomic loci modulating retinal ganglion cell death following elevated IOP in the mouse
por: Struebing, Felix L., et al.
Publicado: (2018)

Detecting IOP Fluctuations in Glaucoma Patients
por: Nuyen, Brenda, et al.
Publicado: (2016)

Effects of Dorzolamide on Retinal and Choroidal Blood Flow in the DBA/2J Mouse Model of Glaucoma
por: Chandra, Saurav, et al.
Publicado: (2016)

Effect of dorzolamide/timolol combination on the visual field in glaucoma
por: Takeda, Sakurako, et al.
Publicado: (2014)

Selective laser trabeculoplasty reduces mean IOP and IOP variation in normal tension glaucoma patients
por: El Mallah, Mohammed K, et al.
Publicado: (2010)

Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
por: Howell, Gareth R., et al.
Publicado: (2007)

Significance of non-intraocular pressure (IOP)-related factors particularly in normal tension glaucoma: Looking beyond IOP
por: Dinakaran, Shoruba, et al.
Publicado: (2022)

Molecular mechanisms of retinal ganglion cell degeneration in glaucoma and future prospects for cell body and axonal protection
por: Munemasa, Yasunari, et al.
Publicado: (2013)

Efficacy and safety of preoperative IOP reduction using a preservative-free fixed combination of dorzolamide/timolol eye drops versus oral acetazolamide and dexamethasone eye drops and assessment of the clinical outcome of trabeculectomy in glaucoma
por: Lorenz, Katrin, et al.
Publicado: (2017)

Measuring Deformation in the Mouse Optic Nerve Head and Peripapillary Sclera
por: Nguyen, Cathy, et al.
Publicado: (2017)

Innovative IOP-Independent Neuroprotection and Neuroregeneration Strategies in the Pipeline for Glaucoma
por: Tsai, James C.
Publicado: (2020)

Comparison between axonal and retinal ganglion cell gene expression in various optic nerve injuries including glaucoma
por: Levkovitch-Verbin, Hani, et al.
Publicado: (2013)

Factors Associated with Vascular Changes at the Level of Retinal Ganglion Cell Axon versus Soma/Dendrite in Glaucoma Patients
por: Oh, Si-Eun, et al.
Publicado: (2023)

Efficacy, safety and tolerability of combination therapy with timolol and dorzolamide in glaucoma and ocular hypertension
por: Ichhpujani, Parul, et al.
Publicado: (2010)

Latanoprost and Dorzolamide for the Treatment of Pediatric Glaucoma: The Glaucoma Italian Pediatric Study (Gipsy), Design and Baseline Characteristics
por: Quaranta, Luciano, et al.
Publicado: (2016)

Intrinsically photosensitive retinal ganglion cells in glaucoma
por: Gao, Jingyi, et al.
Publicado: (2022)

Axonal transport of actin in rabbit retinal ganglion cells
Publicado: (1979)

Gene therapy and the regeneration of retinal ganglion cell axons
por: Harvey, Alan R.
Publicado: (2014)

Caspases in retinal ganglion cell death and axon regeneration
por: Thomas, Chloe N, et al.
Publicado: (2017)

Extraretinal Spike Normalization in Retinal Ganglion Cell Axons
por: Fogli Iseppe, Alex, et al.
Publicado: (2020)

Inter-eye correlation analysis of 24-h IOPs and glaucoma progression
por: Dakroub, Mohamad, et al.
Publicado: (2022)

Pathogenesis of glaucoma: how to prevent ganglion cell from axonal destruction?
por: Carreras, Francisco Javier
Publicado: (2014)

DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma
por: Kim, K-Y, et al.
Publicado: (2015)

Quantitative Microstructural Analysis of Cellular and Tissue Remodeling in Human Glaucoma Optic Nerve Head
por: Guan, Carolyn, et al.
Publicado: (2022)

Rational use of the fixed combination of dorzolamide – timolol in the management of raised intraocular pressure and glaucoma
por: Yeh, Jason, et al.
Publicado: (2008)

Development of Dorzolamide Loaded 6-O-Carboxymethyl Chitosan Nanoparticles for Open Angle Glaucoma
por: Shinde, Ujwala, et al.
Publicado: (2013)

Retinal ganglion cell axonal compression by retinal vessels in light-induced retinal degeneration
por: García-Ayuso, Diego, et al.
Publicado: (2011)

Changes in axonally transported proteins during axon regeneration in toad retinal ganglion cells
Publicado: (1981)

Cannot write session to /tmp/vufind_sessions/sess_pl3663c2ltlhag1dfrbmvplhl2