Six-helix bundle completion in the distal C-terminal heptad repeat region of gp41 is required for efficient human immunodeficiency virus type 1 infection

BACKGROUND: The native pre-fusion structure of gp120/gp41 complex of human immunodeficiency virus type 1 was recently revealed. In the model, the helices of gp41 (α6, α7, α8, and α9) form a four-helix collar underneath trimeric gp120. Gp41 is a class I fusion protein and mediates membrane fusion by...

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Detalles Bibliográficos
Autores principales: Liu, Dehua, Wang, Hongyun, Yamamoto, Mizuki, Song, Jiping, Zhang, Rui, Du, Qingling, Kawaguchi, Yasushi, Inoue, Jun-ichiro, Matsuda, Zene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879932/
https://www.ncbi.nlm.nih.gov/pubmed/29609648
http://dx.doi.org/10.1186/s12977-018-0410-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879932/
https://www.ncbi.nlm.nih.gov/pubmed/29609648
http://dx.doi.org/10.1186/s12977-018-0410-9

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